Background: Under local or general anesthesia, middle ear surgeries (mastoidectomy and tympanoplasty) are complicated by a high rate of postoperative nausea and vomiting. The present study evaluated the role of intravenous dextrose on reducing postoperative nausea and vomiting during middle ear surgeries. Materials & Methods: 80 healthy patients scheduled for tympanoplasty under general anesthesia of both genderswere divided into 2 groups of 40 each. Group I received Ringer’s lactate solution and group II received 5% dextrose in Ringer’s lactate solution intravenously following surgery. Postoperative nausea and vomiting scores, antiemetic doses were recorded. Results: The mean duration of surgery (min) was 104.2 and 103.5, duration of anaesthesia (min) was 118.3 and 119.0, intra-operative narcotic used (mg) was 115.4 and 115.7 and intra-operative blood loss (ml) was 18.4 and 17.5 in group I and II respectively. PON was seen in 20 and 15, POV in 4 and 3 in group I and II respectively. Average emetic episodes was 1.7 and 0.82, antiemetic used per individual (mg) was 3.2 and 1.4 and mean duration of stay in PACU (min) was 184.2 and 140.7 in group I and II respectively. The difference was significant (P< 0.05). Conclusion: By reducing the amount of rescue antiemetic used and the length of stay in the post-anesthesia care unit, a postoperative 5% intravenous infusion of dextrose led to better management of postoperative emesis.