Introduction: Drug-drug interactions (DDIs) are a frequent challenge in clinical settings, especially among hospitalized patients with complex, often chronic, medical conditions that require multiple medications. Objective: The main objective of the study is to find the prevalence and comparative analysis of potential drug-drug interactions among hospitalized patients at different cardiac institutes.Methodology: This retrospective cross-sectional study was conducted and data were collected from 284 patients admitted to various cardiac institutes. Patient medical records were thoroughly reviewed to gather essential information for this study. Data collected included demographic details such as age, gender, and weight, alongside clinical information, including diagnoses at admission, comorbidities, and past medical history.Results: Data were collected from 284 patients with a mean age of 59.01±5.67 years, of whom 60% were male and 40% female. On average, patients were prescribed five medications during their hospital stay, and a substantial 75% had comorbid conditions. Approximately 69.7% of patients experienced at least one pDDI, with 45% of interactions classified as major. Cardiovascular drugs, particularly antithrombotic agents, beta-blockers, and calcium channel blockers, were frequently involved in major DDIs. Conclusion: It is concluded that potential drug-drug interactions (pDDIs) are highly prevalent among hospitalized cardiac patients, particularly among older adults and those with complex comorbidities.