Background: Staphylococcus aureus is associated with different infections ranging from skin and soft tissue infections to endocarditis and fatal pneumonia. S. aureus is still the most common bacterial species isolated from inpatient specimens and the second most common from outpatient specimens. Today, methicillin resistant S. aureus (MRSA) isolates are present in the hospitals of most countries and are often resistant to several antibiotics. Aims & Objectives: To study the antibiotic resistance pattern of MRSA to commonly used and newer antibiotics. Materials & Methods: A total of 140 isolates of methicillin resistant S. aureus were collected from various pus, blood, Catheter tips and urine. All isolates were identified at the species level by standard biochemical tests. Susceptibility to eight antibiotics was determined by disc diffusion method. Antibiotic disc were applied within 15 minutes of inoculation and the plates were incubated at 370C for 18-24 hours.Zone diameters were measured as per CLSI criteria. Results:Among a total of 140strains were found to be MRSA isolates. All the isolates showed 100% resistant to Ampicillin, Erythromycin and Ciprofloxacin followed by Cotrimoxazole (62.1%),Clindamycin (53%) and Amikacin (10%). No strain showed resistant to Rifampicin, Vancomycin, Linezolid, Daptomycin, Tigecycline, Teicoplanin,Ceftaroline Conclusion:The high isolation rates of MRSA from all the age groups of patients, attending all most all the departments of our hospital and their high resistance to commonly used antibiotics is a cause of concern