Background: Caudal analgesia is an effective, reliable, and straightforward method for providing analgesia both during and after Pediatric infraumbilical surgery. The present study compared dexamethasone and dexmedetomidine when used as an adjuvant to bupivacaine to caudal epidural block in children undergoing infraumbilical surgeries. Materials &Methods: It comprised of84 pediatric patients age ranged 1-10 years of either gender scheduled for infraumbilical surgery. Patients were divided into 3 groups of 24 each. In group I (control), the patients received Inj Bupivacaine 0.25% :1 ml/kg + normal saline 0.9%-1ml. In group II, the patients received Inj. Bupivacaine 0.25%: 1 ml/kg + Injdexamethasone (0.1 mg/kg) making volume to 1 ml. In group III, the patients received Inj Bupivacaine 0.25%: 1 ml/kg + Injdexmedetomidine (1 µg/kg) making volume to 1 ml. Parameters such as time of analgesia (min), Ramsay sedation score, the modified objective pain score (MOPS) was assessed. The adverse effects in PACU also were assessed. Results: Group I had 15 males and 9 females, group II had 14 males and 10 females and group III had 11 males and 13 females. The mean weight was 20.2 kgs in group I, 19.6 kgs in group II and 19.7 kgs in group III patients. ASA grade I/II was seen in 12/12 in group I, 11/13 in group II and 10/14 in group III. The mean duration of analgesia was 316.4 minutes in group I, 486.2 minutes in group II and 492.6 minutes in group III. The difference was non- significant (P> 0.05). At 30 minutes, the MOPS was 3, 4 and 3 in group I, II and III respectively. At 1 hour, it was 4, 4 and 3, at 3 hours was 3, 3 and 3 and 6 hours was 3, 2 and 1 in group I, II and III respectively. There was significant difference mean Ramsay sedation score (P< 0.05). Adverse events reported were bradycardia in 1 in group I, 2 in group II and 4 in group III. Hypotension was 2 in group I, 1 each in group II and III. Vomiting 3 in group I, 2 in group II and 1 in group III. Conclusion: Caudal dexmedetomidine is better adjuvant in prolongation of postoperative analgesia compared to caudal local anesthetic alone or with dexamethasone. Also, they showed comparable side effects profile except bradycardia which was marginally higher with dexmedetomidine.