Background: Poisoning remains a significant public health concern worldwide, with its impacts varying considerably across different regions and populations due to a range of socio-epidemiological factors. It encompasses a broad spectrum of substances, including pharmaceuticals, pesticides, household chemicals, and natural toxins, leading to a diverse array of clinical presentations and outcomes.Material and Methods: This retrospective study was conducted in the Department of Forensic Medicine and Toxicology, with a total of 200 poisoning victims whose autopsies were performed. Internal and external findings during the autopsy were documented, and specimens were sent for chemical analysis. Detailed histories were obtained from the relevant investigating officer, relatives, and hospital records. The inclusion criteria were poisoning victims whose bodies were autopsied at the hospital mortuary. Exclusion criteria included homicidal, unknown, and decomposed bodies. Data from inquest reports, police documents, autopsy records, and chemical analysis reports were analyzed and compared with similar studies.Results: The majority of poisoning cases occurred in individuals aged 21-30 years (25%), followed by the 31-40 age group (20%). Males constituted 60% of the victims, while females accounted for 40%. Most victims (70%) were literate, and 50% were married. Nuclear family structures accounted for 75% of the cases. Low socio-economic status was prevalent among 60% of the victims. Organo-phosphorous compounds were the most commonly consumed poisons (30%), followed by organo-chlorine compounds (15%). Aluminium and zinc phosphide, corrosive acids, and plant poisons also contributed to poisoning incidents.Conclusion: This study highlights the socio-epidemiological factors influencing poisoning cases, with younger adults and males being more affected. Organo-phosphorous compounds emerged as the most common poison, particularly in agricultural settings. Socio-economic status played a significant role, with low-income individuals being more vulnerable. The findings emphasize the need for preventive strategies, better regulations, and awareness programs, especially in high-risk populations.