Background: Preterm premature rupture of membranes (PPROM) affects approximately 3% of pregnancies and significantly increases the risk of preterm birth and chorioamnionitis, a serious inflammatory condition. Early diagnosis of chorioamnionitis is crucial for improving maternal and neonatal outcomes. Objectives: This study aimed to investigate the association between serial C-reactive protein (CRP) levels and the development of chorioamnionitis in women with PPROM, to evaluate the diagnostic accuracy of CRP at admission, and whether serial CRP would improve diagnostic accuracy Methods: We conducted a prospective observational study involving 104 pregnant women with gestational ages between 28 to 34 weeks, diagnosed with PPROM. Participants underwent CRP testing at admission and again 48 hours later. Clinical signs of chorioamnionitis were monitored, and data were analysed using appropriate statistical methods. Result: The incidence of clinical chorioamnionitis was found to be 15.4%. Participants who developed chorioamnionitis had significantly higher mean CRP levels at admission (41.8 mg/L) compared to those without (12.1 mg/L, p<0.001). A CRP cut-off value of ≥17.9 mg/L at admission demonstrated high sensitivity (87.5%) and acceptable specificity (59.1%) for predicting chorioamnionitis. Serial CRP measurements improved diagnostic accuracy to 85.6%, compared to the previous diagnostic accuracy of 63.5%. Conclusion: This study reinforces the utility of CRP as a reliable biomarker for predicting chorioamnionitis in patients with PPROM. The findings support the use of serial CRP monitoring in clinical practice to enhance the management of at-risk pregnancies, ultimately improving maternal and neonatal outcomes. Further research with larger cohorts is needed to confirm these results and establish standardized protocols.