Background: Cysts in the oral and maxillofacial region can be classified as either odontogenic or non-odontogenic based on the origin of the cyst's epithelial lining. The present study was clinico- pathological analysis of odontogenic cysts and tumors. Materials & Methods: 104 cases of odontogenic cysts and tumours of both genders were analyzed for the location in the maxilla and mandible. The type and number of cysts, as well as lesion location, were noted. Tumor histopathologic type was recorded. Results: Out of 104 patients, 54 were males and 50 were females. Common cyst was radicular cyst in 28, residual cyst in 4, gingival cyst in 6, Botyroid odontogenic cyst in 4, dentigerous cyst in 5, OKC in 10, and lateral periodontal cyst in 3 cases. Maxillary anterior region was involved in 11 cases, and posterior region in 9, mandibular anterior region in 12 and posterior region in 28 cases. The difference was significant (P< 0.05). Tumors in ant maxilla, ant mandible, post. max and post. mandible were Ameloblastoma in 1, 2, 5 and 12. AOT was seen in 1, 1, 1 and 0. CEOT was seen in 2, 1, 0, and 1. Odontogenic fibroma was seen in 0, 0, 1 and 1. Cementoblastoma was seen in 0, 0, 0, and 1 case. Odontoma was seen in 2, 2, 3 and 5 cases respectively. The difference was significant (P< 0.05). Conclusion: Radicular cyst was most common odontogenic cyst. Ameloblastoma was commonly occurring odontogenic tumour. The majority of cases involved the mandibular posterior region.