Background: When anesthesia is given, inhaled anesthetics are more likely than intravenous anesthetics to enter the middle ear (ME) region and change ME status by increasing MEP. The present study was conducted to compare the effects of sevoflurane and isoflurane on middle ear pressure. Materials & Methods: 90 cases of both genders visiting ENT departmentwere divided into two groups of 45. Patients in group I were given isoflurane and group II sevoflurane. Tympanometric functions were evaluated using a middle ear analyzer to confirm the patients' routine immitance screening for ME. The type A curve classification approach, which covers the typical MEP ranges of -100 to +500 daPa, was used to make tympanometric measurements. The following times were recorded: T0, when the patient was seated the day before the procedure; T1, when the patient was supine on the operating table prior to the procedure; T2, after the induction of anesthesia and endotracheal intubation; and T3, just after the anesthetic was removed (T3). Results: The mean weight in group I patients was 36.5 kgs and group II patients was 34.7 kgs, height was 123.4 cm in group I and 124.4 cm in group II. ASA grade I was seen in 20 and II in 25 in group I and grade I in 28 and II in 17 in group II. Time of surgery was 35.2 minutes in group I and 29.5 minutes in group II. The mean time of anesthesia was 51.4 minutes in group I and 50.6 minutes in group II. The difference was non- significant (P> 0.05). The mean middle ear pressure in group I at T0 was -19 at T1 was 27, at T2 was 72 and at T3 was 102 in group I in right ear. It was -20, 31, 82 and 132 at T0, T1, T2 and T3 respectively in group II. It was -18, 35, 87 and 118 in group I and -15, 42, 81 in group I and 140 at T0, T1, T2 and T3 respectively in group II in left ear. The difference non- significant (P> 0.05). Conclusion: Because the rise in middle ear pressure during isoflurane anesthesia was less than that of sevoflurane, it is safe to use during ENT procedures.