Aim: To assess the relation between retinal nerve fiber layer (RNFL) thickness and visual field sensitivity in primary open angle glaucoma in tertiary health care center in northern India. Material and Methods: An observational cross-sectional study conducted involving the 50 patients with signs and symptoms of primary open angle glaucoma who attended the Outpatient Department of Ophthalmology at Maharishi Markandeshwar Deemed to be University, Mullana. To visualize the anterior chamber angle, gonioscopy was performed on each patient and the results were rated using the Schaffer grading method. All patients had the thickness of the RNFL assessed using the SD-OCT. Visual field defects were observed using the perimetry process and the correlation between RNFL thickness and visual field defect was examined. The level of significance was set at p < 0.05. Results: Male individuals made up 64% of the sample. The mean pattern standard deviation (PSD) for mild, moderate and severe POAG subjects was 3.79±2.42, 7.53±2.98 and 10.66±2.85, respectively. The RNFL thickness (μm) for participants with mild, moderate and severe POAG was 102.81, 83.67 and 62.95, respectively. Conclusion: There was a strong correlation between changes in the visual field and the RNFL thickness and optic disc characteristics in the POAG group. OCT can identify RNFL abnormalities in individuals suspected of having glaucoma whose disc and visual fields appear normal.