Background: Acute pancreatitis may follow a mild or severe course. Whereas mild or edematous pancreatitis is a self-limiting disease with a low complication rate and low death rate, morbidity and mortality in severe or necrotizing pancreatitis are still unacceptable. The major problem is the lack of a specific drug, especially in the early phase of the disease, to interfere with the systemic inflammatory response syndrome and to limit or prevent complications of the disease. Aim and objective: A Role of Octreotide in Preventing Complications of Acute Pancreatitis. Material and Method: This case control study was done on patients admitted for the treatment of acute pancreatitis at a tertiary care teaching hospital in VIMS, Gajraula, UP, India. This is a retrospective study. The data on inpatient records were taken from the medical records department (MRD) of the hospital. The diagnosis of patients was established on the basis of biochemical and radiological investigations. The patients were divided into two groups: cases and controls. Cases had received octreotide along with fluids (group A); controls received fluids without octreotide (group B). Symptomatic treatment was given in both groups. Ages of the cases and controls were matched (±3 years). The statistical analysis of the data was done, and results were obtained. Results: In this retrospective case-control study, the records of 50 patients were selected. The mean age in the octreotide group (Group A) was 35.16±8.65 years when compared with 37.92±7.1 years in Group B (p < 0.211). Gender-wise comparison showed that there were 20 males and 5 females in the octreotide group, while there were 20 males and 5 females in the control group. Both the groups were comparable. All the patients in the octreotide group survived, while there were three in the control group. As far as the mean hospital stay is concerned, it was 9.88 days ± 6.0 in group A, while it was 7.24 days ±1.17 in group B. All the p values for the criteria of the study are significant. But when we talk about percentage, 8% of patients died in the control group. Conclusion: In our study, we found that octreotide does not affect the final outcome of patients with acute pancreatitis. There is no effect on hospital stay and reduced need of analgesics in patients with acute pancreatitis.