Background: Esophageal varices (EV) are a common complication of liver cirrhosis, and early detection is crucial for preventing life-threatening bleeding. Objectives: To evaluate the accuracy of non-endoscopic predictors of EV in liver cirrhosis and identify potential predictors for risk stratification. Materials and Method: This observational analytical cross-sectional study included 65 patients with liver cirrhosis. Non-endoscopic parameters such as platelet count, spleen size, portal vein diameter, and Child-Pugh score were assessed and correlated with EV severity. Results: A statistically significant decline in mean platelet count was observed with increasing EV severity (F value = 4.578, p = 0.003). The mean platelet count to spleen diameter ratio also showed a statistically significant difference among groups (F value = 4.173, p = 0.005). However, no significant differences were found in mean spleen size, portal vein diameter, and ChildPugh scores among different EV grades. Conclusion: Platelet count and platelet count to spleen diameter ratio may be useful non-endoscopic predictors of EV in liver cirrhosis. These findings can aid in risk stratification and guide clinical decision-making.