Background: Drug prescription pattern monitoring (DPPM) study is an important tool to evaluate, understand and improve the prescribing pattern. Objective: To evaluate the prescription pattern of drugs in the Medical ICU using WHO prescribing Indicators. Materials and Methods: This was a Cross-sectional study conducted from July 2023 to December 2023 in Government Medical College & Hospital,Kallakurichi, Tamilnadu among case records of 138 patients. Demographic details, diagnosis and drug details recorded from case sheets were documented in the data entry format, analyzed and inference was obtained by applying Descriptive statistics. Result: The mean age of the patients was found to be 52.7 approximately and their age range varied from 19 to 85 years. The average stay of patients in the Medical ICU was 4.05 days. 78% of Generic and 14% of Branded drugs were prescribed. The proportion of usage of single constituent drug was 96.5% and fixed dose combination drugs was 3.4%. Diabetes mellitus and coronary artery diseases were the most common comorbid diseases followed by Hypertension. Most of the patients were prescribed oral drugs (56%) followed by parenteral drugs (32%). Ranitidine (62.5%) is the most commonly prescribed drug followed by Atorvastatin (32.6%). Cephalosporins (47.1%) was the most commonly prescribed antibiotic followed by penicillin (21.01%). Conclusion: Our study shows that the percentage of antibiotic usage was low as compare to WHO standard value. The average number of drugs prescribed per prescription and parenteral route of administration was higher than that of WHO values. Usage of generic drugs can be improved.