Aim: To evaluate the features of intracranial lesions on diffusion weighted magnetic resonance imaging. Materials and methods: The present hospital-based prospective observational study was conducted in the Department of Radiology, Muzaffarnagar Medical College, Muzaffarnagar, U.P. for 18 months duration among 50 patients who were detected to have intracranial lesions on MRI brain. Relevant clinical history and examination were noted. The DWI findings were noted and correlated with ADC and T2 FLAIR images. For evaluation of the brain, MRI was performed using a 1.5 tesla MRI scanner (MAGNETOM ESSENZA SIEMENS). Sagittal T1, axial T2 FLAIR and diffusion-weighted images with ADC maps were taken. Results: Most common diagnosis among the study subjects was acute infarct (32%). 34 cases (68%) showed hyperintensity on DWI of which true restriction (hyperintense on DWI and hypointense on ADC) was noted in 31 patients (62%). There were 6 cases of intra axial tumors in this study, out of which 4 cases (66.7%) showed true diffusion restriction. Of these were 1 were GBM, 1 medulloblastomas, and one was lymphoma and 1 case of cerebral metastasis. In 2 cases of oligodendroglioma ADC signal was increased in all, suggesting increased water diffusivity. 10 cases of extra axial tumors were included in this study. Conclusion: Diffusion-weighted MRI is a valuable technique that provides unique information about the physiological state of brain tissue. By using a combination of various MR sequences coupled with DWI and ADC images a valuable diagnosis may be provided to the clinicians.