Background: Patients undergoing lower abdominal surgeries experience postoperative pain which delays their early recovery, ambulation and lengthens the hospital stay. The abdominal blocks help in providing postoperative analgesia to a greater extent. This study aims to compare the effect of bilateral Quadratus lumborum (QL) block versus bilateral Transversus abdominis plane (TAP) block for postoperative analgesia in patients posted for total abdominal hysterectomy under general anaesthesia. Methodology: In this comparative prospective study sixty female patients of ASA grade 1 and 2, posted for total abdominal hysterectomy under general anaesthesia were randomized into two groups. After giving general anaesthesia, before taking the incision in Group Q (Quadratus lumborum block) or Group T (Transversus abdominis plane block) infiltration was given with 0.25% of bupivacaine 20 ml bilaterally. We compared intraoperative total usage of opioids, muscle relaxants and postoperative time for rescue analgesia in both the groups. All the patients were assessed postoperatively for severity of pain using Visual Analogue Scale (VAS) score. Time before rescue analgesia and total requirement of analgesic in the postoperative period were noted. Results: In comparison to group T, Group Q had lower VAS scores at each point in 24 hours. Time before rescue analgesia was much longer in Group Q (14.43±2.885 versus 8±2.464) when compared to group T. The total requirement of analgesic in the postoperative period was significantly lower in Group Q (35.83±19.346 versus 60±20.342). Postoperative analgesia provided by QL block had a longer duration of action and required less consumption of analgesic in the postoperative period.