Background: Writing a prescription is a science, and interacting with patients is an art. Various factors might influence the prescription practice, potentially resulting in irrational drug use. The present study evaluated pattern of drug use in acute fever by general practitioners (GPs). Materials &Methods: 120 general practitioners such as MBBS and BAMS doctors of both genders were selected. Parameters such as the average number of drugs per encounter, the percentage of the drugs which were prescribed by their generic names, the percentage of the encounters with an antibiotic which was prescribed, the percentage of the encounters with an injection which was prescribed, the percentage of the drugs from an essential drug list (EDL) or a formulary was recorded. Results: Out of 120 GPs, 75 were males and 45 were females.% of prescriptions with injections was 5% by MBBS and 17% by BAMS, % of prescriptions with antibiotics was 62%and 90%, % of drugs from essential drug list was 58% and 52%, % of drugs from generics was 24% and 32% by MBBS and BAMS respectively. The difference was significant (P< 0.05).Antimicrobial agents used by MBBS and BAMS doctors were Penicillins in 56% and 42%, Cephalosporins in 20% and 25%, Macrolides in 14% and 13%, fluoroquinolones in 3% and 15% and no antibiotics in 7% and 5% doctors respectively. The difference was significant (P< 0.05). Conclusion: The WHO prescribing core drug usage indicators among the BAMS GPs were all noticeably anomalous, and the rate of incorrect prescriptions was startlingly high.