Background: Post-operative residual curarization (PORC) has been a concern for over 40 years, particularly with the use of long-acting neuromuscular blocking agents. Even with the introduction of intermediate-acting agents, studies continue to highlight the prevalence of PORC. Question: This study aimed to determine and compare the residual neuromuscular blockade in the immediate post-operative period after balanced general anaesthesia using cis-atracurium, rocuronium, and vecuronium. Methods: We conducted a prospective, randomized, single-blinded study over 18 months in the Department of Anaesthesiology and Intensive Care at our tertiary care hospital. A total of 150 patients were included in the study according to the inclusion and exclusion criteria. Results: Our findings indicated that residual neuromuscular blockade was less pronounced in the cis-atracurium and vecuronium groups, while it was more prominent in the rocuronium group immediately after surgery. However, at the 30-minute mark, significant paralysis was observed with vecuronium only. No significant paralysis was noted with any of the groups one and a half hours after extubation. Hemodynamic parameters during general anaesthesia were more favourable with cis-atracurium and vecuronium both intraoperatively and postoperatively. Conclusion: Cis-atracurium emerges as the preferred drug due to its minimal post-operative residual neuromuscular paralysis. Cis-atracurium at 0.15 mg/kg and vecuronium at 0.1 mg/kg exhibited a slower onset of action compared to rocuronium at 0.6 mg/kg and provided excellent intubating conditions in most patients after 180 seconds. Although slight tachycardia was observed in the rocuronium group, it remained within normal vital limits (HR < 100/minute), while slight bradycardia was noted in the cis-atracurium and vecuronium groups (HR > 60/minute) during the intraoperative period.