Background: According to WHO, low birth weight (LBW) refers to birth weight <2500 grams (5.5 pounds). LBW is the main cause of newborn morbidity and death. Jaundice affects 60–70% of all term babies to some extent, but it affects 80% of low-birth-weight babies, of whom 4–6% have severe neonatal hyperbilirubinemia. Compared to neonates of normal birth weight, LBW babies are more vulnerable to hyperbilirubinemia-related brain damage and other complications at lower bilirubin levels. Objective: Present study aims to investigate the incidence of neonatal jaundice requiring intervention in LBW babies in a tertiary care centre and to compare the profile of jaundice in LBW infants between the AGA and SGA subgroups. Methodology:100 neonates born with birth weight <2.5kgs were included in the study. The infants were classified as AGA if the weight for GA was between the 10th to 90th centile and SGA if the weight is less than the 10th centile for the GA. A separate category was made for weight less than 3rd centile. Results:44% subjects were AGA and 56% were SGA and a higher proportion of female gender (55%) was observed in study population. Mean TSB was 14.66 ± 2.99 in AGA group and 14.46 ± 2.99 in SGA group. Phototherapy was administrated in SGA group at significantly higher rates (92.9%) as compared to the AGA group (79.5%). Mean Phototherapy duration was also significantly higher in the SGA group (30.03 ± 8.01) as compared to the AGA group (26.74 ± 6.40). Conclusion: Rate of phototherapy andmean phototherapy duration was significantly higher in the SGA group as compared to the AGA group.More studies with ample sample size are required to validate the findings of present study.