Objective: The objective of this research is to investigate the correlation between cardiac biomarkers and to evaluate their use in risk assessment.Methods: Hospital based prospective study which was undertaken by the cardiology department and biochemistry department of Government Medical college and Hospital Srikakulam, Andhra Pradesh on 40 patients who attended to the OPD. The patients were assessed for myocardial infarction biomarkers in conjunction with their clinical characteristics.Results: The study found that males predominantly had Myocardial Infarction than females. Hs-CRP, CKMB, TnT, and MPO levels were significantly higher (p<0.05) in the patients who were having MI. hs-CRP, CKMB, TnT, and MPO have a very strong connection with myocardial infarction, which is statistically significant. When cardiac muscle is injured, CKMB and TnT are released. Leukocytes generate myeloperoxidase (MPO), which causes inflammation. The association between age and myocardial infarction was weak and non-significant. Gender significantly affects myocardial infarction. hs-CRP, CKMB, TnT, and MPO are strong markers of myocardial infarction risk, whereas age and sex are not so significant. Infarction risk may be better predicted by biomarkers than age and sex, which has major implications for diagnosis and therapy.Conclusion: These cardiac biomarkers may indicate risk and prognosis for myocardial infarction in high-risk people. Further this study observations shows that age and gender are not a reliable risk factors for myocardial infarction.