Background: Pain management during labor has long been enveloped in myths and controversies. Consequently, the quest for effective and safe analgesia during this critical period has posed a persistent challenge. It was shown that an epidural infusion of ropivacaine 0.1% with sufentanil 1 µg mL-1 was highly effective in preventing pain with the specific aim of avoiding motor block. Hence; the present study was conducted for comparative analysis of ropivacaine with sufentanil for epidural anesthesia and spinal-epidural anesthesia in labor analgesia. Materials & Methods: A total of 50 patients were enrolled and were randomized into two study groups as follows: Group 1- Epidural anesthesia group, and Group 2- Spinal-epidural anesthesia group. When the patients were in an advanced stage with no contraindication, we infused 750 mL ringer lactate as an isotonic solution. All the patients received anesthesia according to their respective study groups. The sensory block and pinprick test were assessed for both lower limbs. The motor block was evaluated by modified Bromage scores. Pain was assessed by VAS. The VAS was assessed at the intervals of 5, 10, 30, 60, 90 and 120 min after injection in both groups. Results: Mean age of the patients of group 1 and group 2 was 31.6 years and 28.7 years respectively. Mean weight of the patients of group 1 and group 2 was 78.3 years and 74.9 years respectively. Mean onset of analgesia among patients of group 1 and group 2 was 12.9 mins and 5.9 mins respectively. The mean duration of analgesia among patients of group 1 and group 2 was 118.3 mins and 139.4 mins respectively. The maximum sensory block duration among patients of group 1 and group 2 was 23.9 mins and 10.7 mins respectively. Mean VAS among patients of group 1 was significantly higher in comparison to patients of group 2. Conclusion: Spinal analgesia for labor pain represents a rational and secure approach that not only facilitates a swift recovery in the postpartum period but also ensures effective pain management for the parturient.