Introduction: The success of removable complete or partial denture depends on esthetics, comfort, and function. In anedentulous individual with a complete or a partial denture prosthesis the masticatory load and functional stresses aretransmitted to the bone through mucoperiosteum. These functional stresses lead to chronic soreness, pathologic changes tooral tissues, and subsequent bone loss resulting in loss of accurate adaptation of the denture to the underlying tissues. Softliner materials, when used with ill fitting dentures, are constantly kept in a wet environment of either saliva or denturecleanser that affects their sorption and solubility. These in turn have detrimental effect on other properties. Aim: To evaluatethe effect of denture cleanser on sorption and solubility of different soft liners and tissue conditioners. Materials andmethods: Metal disc was fabricated to make the mould space for soft liner samples. Four materials were used, long term andshort term acrylic liners; long term and short term silicone liners. Each of these were divided into four groups: first controlgroup– all liners were kept in artificial saliva for entire period of study.Second group- liners were immersed daily incleanser for 2 hour and then transferred to artificial saliva for rest of the day. Similarly samples of third and fourth groupswere immersed in cleanser for 6 and 10 hours respectively and transferred to artificial saliva. Sorption and solubility testswere conducted and statistical analysis done. Results: Solubility values of all groups were higher than the quoted ADAspecifications. Conclusion: Overall, silicones performed better than acrylics. Long term silicone was most stable. Short termacrylicwasmostunstable.The10hourimmersionindenturecleansercausedsignificantlyhighsorption andsolubility.