Background and aims: Many studies have proven that with each endotracheal intubation, the chance of sore throats is as high as 21% to 40% which is more evident and significant in people undergoing thyroid surgeries. The occurrence of sore throat postoperatively (POST) after thyroid and neck surgeries have reached upto 80%. This draws attention, how important problem it is, to be solved in clinical practice. Many promising treatments are available for POST, but the clinch in the study comes when prevention of complications is more focused than the treatment part. In light of this, we performed a study on sore throats following thyroid surgeries, where we compared the efficacy of dexamethasone and ketamine in nebulized form. Methods: After satisfying inclusion and exclusion criteria, 90 individuals were selected between the age group of 18–60 years of age, belonging to ASA (American Society of Anesthesiologist) physical status I–II. Participants were allocated randomly into three equal batches, each consisting of 30 individuals. We administered dexamethasone 8 mg in 3 ml of NS as nebulization to batch Dex and ketamine 50 mg in 4 ml of NS as nebulization to batch Ket. On the other hand, the control batch was given 5 ml of normal saline as nebulization for 10–15 minutes before shifting to the operation theater. After induction and endotracheal intubation, these patients were monitored at regular intervals for heart rate (HR) and mean arterial blood pressure (MAP) intraoperatively and postoperatively for the intensity of their sore throat. Results: The frequency and intensity of POST were significantly reduced in the dexamethasone batch compared to the ketamine batch at the following intervals; immediate (P = 0.05), 2 hours (P = 0.05), 6 hours (P = 0.044), and 12 hours (P = 0.028) postoperatively. Conclusion: Prophylactic administration of single dose (8 mg) of nebulized dexamethasone is more effective in reducing the intensity and frequency of sore throats postoperatively than nebulized ketamine (50 mg) in patients undergoing thyroid surgeries following endotracheal intubation.