Bloodstream infections (BSI) are an important cause of morbidity and mortality in hospitalized patients. BSI have been divided into community and nosocomial episodes. Rapid diagnosis, identification of the causative bacteria and appropriate treatment are necessary in mitigating the morbidity and mortality associated with BSIs.To study Microbiological profile of hospital vs community acquired BSI in patients admitted in ICU.This was a prospective study conducted in the department of Microbiology from 1st January 2020 to 31st December 2020. All the patients admitted in medical ICU were included and monitored for BSI. The blood samples received were cultured and antimicrobial susceptibility pattern was determined. 1039 patients were admitted in medical ICU and infections were present in 79(8 %) patients and a total of 80 isolates were obtained. In community acquired (CA) BSI, most common isolate was E coli (31 %) while in hospital acquired (HA) BSI, Klebsiella and Acinetobacter(17 %)were the most common. In HABSI, gram negative isolates showed higher resistance to amikacin (43.4 %), gentamicin (34.7 %) and imipenem(21.7 %) as compared to CA BSI. In CA BSI, MRSA were higher (58.3 %) as compared to HA BSI. Knowledge of antimicrobial resistance pattern provides guidance for the treatment thus improving the outcome.