Background: Depression among patients with diabetes is a significant concern as it can have a negative impact on their health outcomes. Studies have shown that patients with depression and diabetes are less likely to adhere to dietary restrictions and medication, resulting in uncontrolled hyperglycemia and increased complications. The factors associated with depression among diabetic patients vary in different populations and are not adequately studied in central India. The current study aims to analyze the factors associated with these conditions at a tertiary care center in central India. Aim: This cross-sectional study was conducted at a tertiary care hospital in central India aimed to estimate the prevalence of depression among diabetic patients and identify the determinants associated with it. Subjects and Methods: This study recruited 531 patients withdiabetes (more than 1 year) from both rural and urban areas. Demographic, clinical, and diabetes-related information was collected using a semi-structured questionnaire. Depression was assessed using Patient Health Questionnaire-9; a standardized questionnaire. Results: The prevalence of depression among patients with diabetes in the community was found to be 68.73%. Most frequently, depression was mild (257, 48.39%) in nature with moderate depression (108, 20.34%) seen the least. Several factors were found to be positively associated with depression including female gender,duration of diabetesmarital status, and annual health expenditure of more than 10 percent of family income. The presence of diabetic complications and other chronic diseases such ashypertension and obesity also were found to be associated with depression. Conclusion: Depression could be a barrier to the effective treatment of diabetes as it could lead to nonadherence to treatment by the patients. Patients with diabetes must be screened and treated wherever necessary for depression and other common mental disorders. This could improve treatment adherence and consequently better overall diabetes management.