Background: Oral cavity cancer presents a significant health burden, particularly in the Indian subcontinent. Late diagnosis often leads to complex treatment and poorer prognoses. This study aims to analyze the impact of various treatment modalities on symptom relief in oral cavity cancer patients. Materials and Methods: A prospective study was conducted at the Department of ENT, Jhalawar Medical College, Jhalawar, India, between 2022-2023. 50 patients diagnosed with oral cavity cancer were enrolled. Data on demographics, risk factors, tumor characteristics (subsite, type, grade, stage), treatment modalities and pre- and post-treatment symptom severity (pain, bleeding, trismus, swallowing) were collected. The Wilcoxon signed-rank test and Pearson Chi-Square test were used to analyze the data. Results: The majority of patients were male (76%) and presented with early-stage disease (Stage I & II, 54%).The tongue was the most common subsite (46%), followed by the buccal mucosa (34%). Squamous cell carcinoma was the predominant histological type (98%). The most common treatment modality was chemotherapy combined with radiotherapy (44%). A statistically significant reduction in pain was observed post-treatment (p=0.0005). Trismus significantly improved after treatment (p<0.01). Swallowing function showed significant improvement post-treatment (p<0.01). While bleeding improved clinically, the difference was not statistically significant (p=0.111). Conclusion: This study demonstrates that multimodality treatment for oral cavity cancer leads to significant improvement in pain, trismus and swallowing. Early diagnosis and treatment are crucial for better outcomes and improved quality of life for patients.