Introduction: Fine Needle Aspiration Cytology (FNAC) is the primary diagnostic tool for evaluating head and neck lesions. This study aims to correlate FNAC with histopathological findings, evaluating its accuracy, sensitivity, specificity, and predictive values. Methodology: A prospective study was conducted on 72 cases at a tertiary care hospital from June 2022 to May 2023. Results: The study concluded that FNAC has an overall accuracy of 95.6% and is an invaluable tool in diagnosing head and neck lesions, providing a non-invasive means of distinguishing between benign and malignant conditions.