Aim:To study the prevalence and severity of adverse reactions caused by cardiovascular drugs. Materials and Methods: A total of 100 patients, who were prescribed cardiovascular drugs, were enrolled in the study. Patients of both genders, aged 18 years and above, and attending the outpatient clinic for cardiovascular conditions were included. The primary outcome was the rate of adverse reactions among the study population, while the secondary outcome focused on the seriousness of these reactions, including the need for additional medical intervention, discontinuation of the drug, or any fatal outcomes. Results: Adverse drug reactions (ADRs) were observed in 50% of the study participants. Among these, the majority of ADRs were mild, reported by 30% of patients, while 15% of patients experienced moderate ADRs. Severe ADRs were less common, affecting 5% of the study population. The other half of the patients (50%) did not report any ADRs. Among the 20 patients who experienced serious ADRs, 50% required additional medical intervention, demonstrating the clinical significance of these reactions. In 25% of the cases, the severity of the ADRs led to the discontinuation of the drug. Hospitalization was necessary for 20% of the patients, indicating severe adverse effects that could not be managed on an outpatient basis. There was one fatal outcome, representing 5% of the serious ADR cases, underscoring the potential risks associated with cardiovascular drug therapy, even though such outcomes were rare. Conclusion: In conclusion, the study reveals that while cardiovascular drugs are broadly effective, they are associated with a significant rate of adverse drug reactions (ADRs). Half of the participants experienced ADRs, predominantly mild to moderate in severity, with dizziness and hypotension being the most common. Serious ADRs, though less frequent, required medical intervention in 50% of cases, and led to drug discontinuation or hospitalization for a subset of patients.