Diabetic foot infections (DFIs) are a significant cause of morbidity in patients with diabetes, often leading to prolonged hospital stays, recurrent infections, and a high risk of lower limb amputations. Managing DFIs is complex, requiring a multifaceted approach that involves early diagnosis, appropriate antibiotic therapy, timely surgical intervention, and novel adjunctive therapies. This article reviews the current understanding and management strategies for DFIs, emphasizing the critical role of a multidisciplinary approach to improve patient outcomes and reduce the incidence of severe complications, such as osteomyelitis and gangrene.