Background: Heart failure (HF) is a clinical illness that affects people with structural and/or functional abnormalities of the heart that are either acquired or hereditary. The present study was conducted to evaluate relation of serum parathyroid hormone levels with severity and duration of heart failure. Materials & Methods: 70 patients with CCF of both genders were selected. Parameters such as ejection fraction, and NYHA grading was recorded. Serum parathyroid hormone levels were measured by chemiluminescence immunoassay technique. Results: Out of 70 patients, 40 were males and 30 were females. Out of 25 patients with duration >2 years, 16 had serum PTH <72pg/ml and 9 had <72pg/ml. Out of 30 patients with EJ <35%, 12 had serum PTH >72pg/ml and 18 had <72pg/ml. Out of 22 patients with EF 35-40, 7 had serum PTH >72pg/ml and 15 had serum PTH <72pg/ml. Out of 18 with EJ >40, 2 had serum PTH >72pg/ml and 16 had <72pg/ml Out of 43 grade II patients, 14 had serum PTH >72pg/ml and 29 had serum PTH <72pg/ml. Out of 27 grade II patients, 7 had serum PTH >72pg/ml. Out of 25 patients with duration 1-2 years, 24 had serum PTH >72pg/ml and 20 had serum PTH <72pg/ml. The difference was significant (P< 0.05). Conclusion: Both inside and outside of hospitals, elevated rates of cardiac morbidity and death have been associated with blood PTH and other serum-derived indicators of cardiomyocyte necrosis.