Background:Inadequate postoperative pain management is a significant factor in delayed patient recovery and prolonged hospital stays. Research has shown that effective analgesics can provide substantial pain relief, and their combined use can lead to reduced opioid consumption. Therefore, this study aimed to investigate the utilization patterns of analgesics in perioperative cases, with the goal of optimizing pain management strategies and improving patient outcomes.Materials &Methods: The present study was conducted for assessing pattern of utilization of analgesics in perioperative cases. The study involved the recruitment of patients undergoing surgical procedures from various surgical departments, regardless of the specific type of surgery performed. It encompassed all analgesic prescriptions for patients in the peri-operative phase. A total of 156 prescriptions were analyzed. Any modification in the prescribed analgesic or alteration in the method of administration was classified as a new prescription. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Results:An analysis of 156 prescriptions revealed varying patterns of analgesic use across different departments. In the orthopedics department, Paracetamol was the most commonly prescribed analgesic (32.36%), followed by Diclofenac (21.82%), and Paracetamol + Diclofenac (18.18%). Tramadol and Chlorzoxazone + Diclofenac + Paracetamol were prescribed in 5.45% and 18.18% of cases, respectively. In contrast, the general surgery department predominantly prescribed Paracetamol (73.68%), with Diclofenac, Tramadol, and Buprenorphine being prescribed in 21.05%, 2.63%, and 2.63% of cases, respectively. The gynaecology department prescribed Paracetamol (32.43%), Diclofenac (32.43%), and Paracetamol + Diclofenac (27.08%) being the most commonly prescribed analgesics, followed by Tramadol (8.11%).Conclusion: The judicious use of pharmaceuticals encompasses not only the accurate prescribing of medications but also the processes of dispensing and patient adherence. It is essential for hospitals to establish a 'drugs and therapeutic committee' to advocate for appropriate prescribing practices. Teaching hospitals bear a significant obligation to society to foster rational prescribing behaviors among their physicians, thereby influencing future cohorts of medical practitioners. Each teaching hospital should implement its own departmental or institutional prescribing guidelines.