Background:A pathological examination extends beyond merely identifying the cause of death; it plays a significant role in elucidating the pathogenesis and epidemiology of diseases. This examination is instrumental in retrospectively assessing the quality of clinical disease management and in developing new preventive strategies. This study explores the crucial role of histopathological examination in medicolegal autopsies, extending beyond cause of death determination to inform disease management, prevention, and understanding of epidemiological patterns. Materials and Methods:This study examined 100 medicolegal cases submitted for histopathological analysis, excluding those with significant autolytic changes. Pertinent data, including demographics, clinical details, and gross and microscopic findings, were systematically recorded. Tissue sections were processed and stained with hematoxylin and eosin, with inconsistencies between observations documented. Results:Mean age of the cases was 51.9 years. Time since death was 13 hours to 24 hours in 56 percent of the cases while it was between 25 hours to 36 hours in 10 percent of the cases. Time since death was less than 12 hours in 18 percent of the cases. Hepatic steatosis was not identified grossly in 18 cases while it was correctly identified microscopically in 2 cases. Pneumonia was not identified grossly in 7 cases while it was correctly identified microscopically in 20 cases. Histopathological examination was conclusive in ascertaining the specific cause of death in 41 out of 100 cases (41 percent). Conclusion: The microscopic analysis of tissues remains an indispensable component of forensic practice. Therefore, it is essential to complement the macroscopic examination of tissues with microscopic techniques.