Introduction:-Diabetes mellitus is a global health challenge with a growing prevalence, causing complications in various organs and systems, including the cardiovascular system, kidneys, nerves, and eyes. Diabetic retinopathy is a well-documented ocular complication, and diabetes also affects the cornea, the primary refractive surface of the eye.In diabetic patients, the cornea undergoes morphological and functional alterations, including delayed epithelial healing, increased corneal sensitivity, altered tear film stability, and changes in endothelial cell morphology and density. Understanding the extent of corneal endothelial cell loss and CCT changes in diabetic patients can help in early detection of corneal complications and prevention of vision loss. Material and Methods:-This study was conducted at a tertiary care hospital in Rajkot, India, from March 2023 to May 2024involving 1,000 participants. The participants were divided into two groups: 500 diabetic patients and 500 non-diabetic patients. The research aimed to compare ocular parameters, specifically endothelial cell count (ECC) and central corneal thickness (CCT), between diabetic and non-diabetic patients. All patients underwent a comprehensive ophthalmic examination, including endothelial cell count and morphology, corneal and anterior segment examination, and fundus examination.Results:- The study compares endothelial cell density (ECC) and corneal thickness (CCT) in diabetic and non-diabetic patients at a tertiary care center. Results show a significant difference in ECC, indicating lower endothelial cell density in diabetic patients, and a higher CCT in diabetic patients, suggesting an increase in corneal thickness associated with diabetes.Conclusion:- Diabetes significantly impacts corneal endothelial cell count and central corneal thickness, with diabetic patients experiencing reduced ECC and increased CCT, emphasizing the need for regular corneal assessments.