Background: Thyroid hormones play an important physiological role in hematopoiesis, especially erythropoiesis. Erythrocyte abnormalities are frequently associated with thyroid dysfunction especially hypothyroidism. However, hyperthyroidism are rarely investigated and related to the hematological indices and iron profiling in Kashmiri Patients. Objectives: In this study an attempt is made to study hematological parameters and iron profile in hyperthyroidism Patients. Materials and methods: This case-control study included 200 subjects, among which were untreated hyperthyroidism (n=100) and euthyroid (n=100). This study was carried out at Post Graduate Department of Physiology in collaboration with Department of Endocrinology Government Medical College Srinagar. The hematological parameters, Iron and thyroid profile of the subjects were assessed by the Sysmex(Italy) and Allinityi Abbott (USA) automatic analyzer. Results: We evaluated the haematological parameters between untreated hyperthyroidism and euthyroidism in this study group. We discovered that untreated hyperthyroid individuals had considerably lower hematological indices (p<0.001) than euthyroid patients, including Hb, MCV, HCV, RBC, and RDW%. Hb (12.3±1.7 g/dl), RBC (4.4±0.89106/µl), MCV (74.34±9.71 fL), HCT (36.4±2.1%), RDW (14.4±1.8 fL), and RBC% (82.7±12.3%) are the values for untreated hyperthyroidism. These patients may be at risk for anemia and other erythrocyte abnormalities based on their Hb (14.8±1.9 g/dl), RBC (4.9±0.95 106/µl), MCV (84.56±3.84 fL), HCT (39.5±3.1%), RDW (13.5±1.2 fL), and RBC% (84.36±10.36 %). Additionally Ferritin and TIBC levels are higher in hyperthyroid individuals than in controls (p<0.001). Conclusion: The thyroid dysfunction is frequently associated with anemia in subclinical hyperthyroidism. Erythrocyte abnormalities are associated with predisposition of the disease which further leads to imbalance of thyroid hormones and iron profile.