Background:Psoriasis is a chronic dermatological illness that affects 2-3% of the population. The present study was conducted to assess plasma lipid profile in psoriasis patients. Materials & Methods:56 psoriasis patients of both genderswere selected. Psoriasis patients were kept in group I and equal healthy subjects in group II. The blood samples were centrifuged at 3500 rpm for ten minutes. The separated plasma was employed for estimation of total cholesterol, triacylglycerols and HDL cholesterol. Results: Out of 56 patients, 32 were males and 24 were females. In group Iand group II, mean total cholesterol (mg/dl) was 225.8 and 164.3, triacylglycerols (mg/dl) was 245.9 and 118.4, VLDLC (mg/dl) was 50.7 and 27.5, HDLC (mg/dl) was 45.9 and 57.1 and LDLC (mg/dl) was 124.8 and 105.2 respectively. The difference was significant (P< 0.05).in mild, moderate and severe form of psoriasis, mean total cholesterol (mg/dl)was154.3, 189.4 and 225.8, triacylglycerols (mg/dl) was 114.4, 164.4 and 245.9, VLDLC (mg/dl) was 42.1, 45.5 and 50.7, HDLC (mg/dl) was 53.1, 56.2 and 57.2, LDLC (mg/dl)was 112.2, 123.2 and 124.8 respectively. The difference was significant (P< 0.05). Conclusion: Psoriasis patients are vulnerable group for the dyslipidemia induced cardiovascular complications.