Context: Chronic pelvic pain (CPP) is a poorly understood common ailment of females. It is a burden on women’s health with a significant detrimental impact on their quality of life (QOL). The presence of other co-morbidities such as obesity may further worsen the effect of CPP on their QOL. Aim: To study the effects of CPP on quality of life in females of reproductive age group and to determine any association with Body Mass Index (BMI). Settings and Design: An analytical cross-sectional study in a tertiary care setup. Subjects and Methods: Sixty female patients of CPP in the age group of 18–45 years were recruited from the gynecology outpatient department. Age-matched healthy 30 female attendants accompanying CPP patients were recruited as controls. Outcomes measures: Pain scores; visual analogue scale (VAS) score and QOL by the World Health Organization Quality of Life‑BREF (WHOQOL‑BREF) questionnaire. Anthropometric parameters: height, weight, BMI. Statistical Analysis: Unpaired t-test, chi-square test, Pearson correlation coefficient. p-value < 0.05 was considered significant. Results: QOL in CPP patients was significantly lower (p<0.001) in all domains i.e., Physical, Psychological, Social, and Environmental of WHOQOL‑BREF. No significant association was found between the pain scores and various QOL domains. No significant association between BMI and pain scores or between BMI and QOL domains was observed. Conclusions: Chronic pelvic pain has a significant negative effect on the QOL of women with a maximal impact on physical and psychological domains. Our study failed to establish any association between BMI, VAS score, and QOL of CPP patients. We can say that the presence or absence of obesity does not have a significant influence on the pain score and QOL of CPP patients.