Aim:To assess clinico- pathological profile of surgical site infection after general surgery operations.Methodology:Eighty- two patients of surgical site infection of both genders were included. Risk factors of surgical site infections such as length of hospital stay, duration of surgery (in hours), type of procedure, wound classification, American Society of Anesthesiologists physical status score was recorded. Results:Out of 82 patients, males were 38 (46.3%) and females were 44 (53.7%). ASA grade I was seen in 1, grade II in 5, grade III in 30 and grade IV- VI in 46 patients. Age <50 years had 24 and >50 years had 58. Type of procedure was emergency in 52 and elective in 30. Duration of surgery was <1 hour in 22 and >1 hour in 60 cases. Length of hospital stay was <24 hoursin 18 and >24 hours in 64. Wound type was clean- contaminated in 10, contaminated in 22 and dirty in 38 cases. The difference was significant (P< 0.05). Conclusion:Common risk factors for SSI was age >50 years, duration of surgery >1 hour, length of hospital stay>24 hours, dirty wound, emergency surgery and ASA grade IV- VI.