Aim: To assess the association of Lactate, Lactate Albumin Ratio, Procalcitonin and Immature Platelet Fractionin comparison to APACHE IIon admission as marker of severity in sepsis patients Objectives • To assess Lactate / Albumin Ratio ( LAR ) in patients with sepsis. • To assess Lactate value in patients with sepsis . • To assess Procalcitonin ( PCT ) value in patients with sepsis. • To assess Immature Platelet Function ( IPF) value in patients with sepsis. • To compare Lactate, LAR, PCT and IPF with APACHE II score on admission in patients with sepsis for prognostication Material and methods: Hospital based Observational Cross-Sectional Study was conducted at Mahatma Gandhi Hospital , Jaipur between September 2022 to December 2023. Data of 180 patients was collected according to inclusion criteria. Sepsis biomarkers that is Lactate , LAR , IPF , PCT were calculated and were compared to APACHE II score at the time of admission for the purpose of prognostication. Result: Comparing these biomarkers, the Lacto-albumin ratio and Procalcitonin appear to demonstrate stronger associations with disease severity as reflected by APACHE II scores compared to Lactate and IPF. This underscores the importance of multi-parameter assessment in sepsis management to enhance prognostic accuracy and guide therapeutic decisions tailored to individual patient needs. Conclusion: In this study all four markers positively correlated with APACHE II score, that is the level of markers increased along with severity of sepsis. But our study particularly identifies significant associations: APACHE II scores correlate significantly with Procalcitonin and Lacto-albumin ratio. The biomarkers of sepsis used in our study that is Lactate, Lactate Albumin Ratio (LAR) , Immature Platelet Fraction (IPF), Procalcitonin (PCT) can be used to enhance early risk stratification and guide more tailored therapeutic interventions for septic patients .