The COVID-19 pandemic has significantly impacted healthcare workers (HCWs) worldwide. This cross-sectional study aimed to assess the impact of vaccination on the severity and outcome of COVID-19 among HCWs at ESIC Medical College and Hospital, Kalaburagi. The study included 134 vaccinated HCWs and evaluated their vaccination status, COVID-19 infection rates, and symptom severity. Results showed that 25% of vaccinated HCWs contracted COVID-19, with 52% of infections occurring after full vaccination. The majority of infected HCWs experienced mild to moderate symptoms, with no severe cases requiring long-term hospitalization. This study provides valuable insights into the effectiveness of COVID-19 vaccines in reducing disease severity among HCWs.