Tendinopathy represents a common and challenging clinical condition, often resulting in significant pain and functional impairment, it also presents a significant challenge in both sports medicine and general orthopedics due to it’s chronic nature and often limited response to conventional treatments. While various treatment modalities exist, Platelet-Rich Plasma (PRP) and corticosteroid injections are among the most frequently used. ▪ AIMS and Objective: This study aims to compare the efficacy of PRP and corticosteroid injections in the treatment of various tendinopathies. ▪ Material and Methods: A total of 100 patients with diagnosed Tendinopathies were randomly assigned to receive either PRP injection (65 patients) or cortico steroid injection (35 patients) Conditions treated included rotator cuff tendinopathy, Achilles tendinitis, tennis elbow, plantar fasciitis, trigger thumb, and De Quatrain’s disease. The outcomes were evaluated based on pain reduction, functional improvement, and patient satisfaction at 4, 12 and 24 weeks post injection. ▪ Results: The comparative analysis showed that PRP injections led to more significant and sustained pain reduction and functional improvement compared to steroid injections across all tendinopathies treated. PRP was particularly effective in treating rotator cuff tendinopathy, Achilles tendinitis, and tennis elbow, with higher patient satisfaction and fewer side effects. ▪ Conclusion: PRP injections offer a promising alternative to steroid injections for the treatment of tendinopathy, providing better long-term outcomes and higher patient satisfaction. Further large-scale studies are warranted to establish standardized protocols and optimize treatment strategies.