Background: Postpartum haemorrhage (PPH) is one of the commonest causes of maternal morbidity and mortality. It has been believed that an active way for stopping PPH is active managing of third stage of labor. Aim: The aim of this study was to compare the sublingual misoprostol and intravenous oxytocin in the prevention of post-partum haemorrhage after caesarean delivery. Methods: The present Randomized control trial was conducted to compare the effectiveness of sublingual misoprostol 3 dose for prevention of PPH in patient with caesarean delivery. A total 120 subjects were divided into 6 groups namely 400μg, 600μg, & 800μgSublingual Misoprostol and 10IU, 15IU, &20IU intravenous Oxytocinimmediate after opening the peritoneum. Results: The minimum blood loss was observed in 20 unit intravenous oxytocin group and the maximum blood loss, haemoglobin level and total haematocrit value loss was in 400μg sublingual misoprostol group.(p>0.05).while increase the dose of Sublingual misoprostol, reduce the duration of the 3rd stage of labor (p<0.05); while in case of intra venous oxytocin it was insignificantly reduced (p>0.05).The increased incidence of side effects (like shivering, fever, Abdominal Pain, Nausea &vomiting, Hypotension and Tachycardia) with increase dose of sublingual misoprostol and oxytocin. Conclusions: The effectiveness of sublingual misoprostol is similar to intravenous oxytocin in preventing postpartum hemorrhage (PPH) after cesarean delivery and reduces the need for additional uterotonic agents. These findings suggest that lower doses of misoprostol or oxytocin may be as effective as higher doses, but the severity of adverse effects increases with higher doses.