Background: Despite the well-established epidemiological link between high blood pressure and cardiovascular morbidity and mortality, and the substantial evidence supporting the need for antihypertensive therapy, blood pressure control remains inadequate in many cases. Hence; the present study was conducted for comparing the efficacy of different combination of antihypertensive drugs in the treatment of arterial hypertension. Materials & methods: The present study was conducted for comparing the efficacy of different combination of antihypertensive drugs in the treatment of arterial hypertension. A total of 60 patients with presence of arterial hypertension were enrolled. Complete demographic clinical details of all the patients were obtained. A total of three study groups were formed as follows: Group 1: Calcium Channel Blocker (Amlodipine) + Angiotensin Receptor Blocker (Valsartan),Group 2: Angiotensin Receptor Blocker (Valsartan) + Diuretic (Hydrochlorothiazide), and Group 3: Calcium Channel Blocker (Amlodipine) + Angiotensin Receptor Blocker (Valsartan) + Diuretic (Hydrochlorothiazide). Comparison was made among three study groups. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Results: Mean age of the patients of group A, group B and group C was 42.3 years, 45.9 years and 44.1 years respectively. All the three study groups showed significant improvement in the blood pressure posttreatment. However; while comparing in between the individual study groups, maximum improvement was seen among patients of group A. Conclusion: