Introduction – The primary factors contributing to maternal mortality are hemorrhages, infections, botched abortions, and obstructed labor. 25% of these cases are attributed to haemorrhages and can be prevented. One effective intervention is the active management of the third stage of labor (AMTSL). The purpose of this study was to examine the importance of oxytocics in preventing postpartum hemorrhage and to assess the effectiveness of different medicines in managing the third stage of labor. Material and methods- The present prospective study was conducted at department of obstetrics and gynecology of a tertiary care centre among 100 pregnant women during the study period of one year. Four group were made on the basis of oxytocic drug given. Results were analyzed using SPSS version 25.0. Results- There was no statistically significant difference in the average amount of blood loss across the groups when considering factors such as parity and type of labor. Based on the current research, it appears that no oxytocic medication has demonstrated superiority over others in lowering blood loss. Misoprostol has a varying time period before it begins to take effect. The average duration of the third stage is consistent across different groups. Regarding side effects, group I and II the most common side effect was temperature and in group III and IV was nausea. Conclusion- The study determined that all uterotonics possess certain benefits, however, oxytocin is considered the optimal medication of choice in the hands of a professional practitioner due to its precise and immediate commencement of action.