Background: Despite notable progress in prevention and treatment, coronary artery disease (CAD) continues to be the most common cause of mortality and one of the primary causes of ischemic heart disease.The present study was conducted to assess correlation between cardiac enzyme markers and lipid profiles in coronary artery disease. Materials & Methods: The study was conducted at Department of Medicine, Patna Medical College and Hospital, Patna during Jan 2023 - June 2023. 36 patients with coronary artery disease of both genderswere put in group I and healthy control in group II. 5ml blood samples were collected under aseptic precautions for the estimation of lipid profile and cardiac enzymes such as total cholesterol, triglycerides, LDL, HDL, CK-MB, AST. Results: Out of 36 patients, males were 20 and females were 16. Total cholesterol was 231.6 mg/dl in group I and 170.5 mg/dl in group II. LDL was 143.8 mg/dl in group I and 115.0 mg/dl in group II. HDLwas 52.9 mg/dl in group I and 42.7 mg/dl in group II. TG was 124.6 mg/dl in group I and 105.3 mg/dl in group II. The difference was significant (P< 0.05). The mean CK- MB level in group I was 56.3 and in group II was 17.4. AST level was 75.8 in group I and 25.9 in group II.The difference was significant (P< 0.05). There was significant positive correlation between CK-MB and AST =. CK- MB showed positive correlation between TC, LDL, HDL and TG. AST showed positive correlation between TC, LDL, TG and negative correlation between HDL. Conclusion: There was a notable positive connection between CK-MB and AST. On the other hand, there is no discernible relationship between TC, HDL, and LDL. The assessment of lipid parameters and cardiac enzyme indicators in CAD patients would be used as a tool for future prevention of coronary artery disease patients, either for medication or lifestyle changes.