Background: Total knee arthroplasty (TKA) is one of the most cost-effective and consistently successful surgeries performed in orthopedics. Hence; the present study was conducted for assessing impact of tranexamic acid during total knee arthroplasty in Reduction of blood loss. Materials & methods: 40 individuals were admitted to this facility for total knee arthroplasty, and were then separated into two groups through random allocation. Group A consisted of 20 patients who received intravenous tranexamic acid, while Group B consisted of 20 patients who did not receive tranexamic acid. A tourniquet was utilized in each case at the correct pressure and for the appropriate length of time. Tranexamic acid was administered 30 minutes before the operation. The quantity of blood loss was measured and all findings were documented and examined using SPSS software. Results: The average perioperative blood loss for patients in group 1 was 353.2 ml, while for those in group 2 it was 524.8 ml. Upon statistical comparison, it was evident that the mean perioperative blood loss was significantly higher in group 1 patients compared to group 2 patients. The average postoperative blood loss for patients in group 1 was 813.9 ml, whereas for group 2 patients it was 1275.9 ml. Upon comparing the mean postoperative blood loss, it was observed that subjects in group 1 had a significantly lower amount of postoperative blood loss compared to subjects in group 2. Conclusion: TXA may play a part in improving the general conditions of patients given TKA by maintaining a hemodynamically stable state and reducing the chance of transfusion-associated side effects and complications.