Aim and objectives: To study the Clinical profile of patients with oral mucosal lesions visiting the Dermatology OPD in a Tertiary Care Medical College Hospital in South Bihar. Materials and method: The present study was conducted after clearance from Board of Studies, and Ethical committee in the Department of dermatology, venereology & leprology. Results: Among Auto-immune diseases, symptomatic oral lesions were significantly more among lichen planus, psoriasis, pemphigus vulgaris and bullous pemphigoid patients. Conclusion: Most of the time, oral manifestations may be found as an initial symptom in patients with dermatological lesions.