Aim: To assess the effectiveness of the critical view of safety (CVS) technique in laparoscopic cholecystectomy for preventing bile duct injuries. Materials and Methods: A total of 50 consecutive patients diagnosed with gallbladder disease were included in the study. The exclusion criteria were defined to ensure the safety and appropriateness of the procedure. Clinical manifestations related to gallbladder disease were recorded, and patients were categorized based on aberrant anatomy and the presence of spillage during the surgery. Preoperative hematological and biochemical profiles were assessed for all patients to establish baseline health status.All patients underwent laparoscopic cholecystectomy performed by skilled and experienced surgeons. Results: The clinical manifestations and the occurrence of aberrant anatomy among the patients. Abdominal pain was the most common symptom, reported by 90% of patients. Nausea and vomiting were present in 40% of the patients, and jaundice was observed in 10%. Regarding anatomical variations, 20% of the patients exhibited aberrant anatomy, while 80% did not. Intraoperative spillage occurred in 10% of the cases, while 90% of the surgeries proceeded without spillage.The postoperative outcomes, including pain levels, infection rates, recovery times, and the incidence of bile duct injury. Pain was predominantly mild (VAS score 0-3) in 70% of the patients, with 20% experiencing moderate pain (VAS score 4-6) and 10% severe pain (VAS score 7-10). Only 4% of the patients developed postoperative infections, while 96% had no infections. Recovery time was ≤3 days for 60% of the patients, 4-7 days for 30%, and more than 7 days for 10%. Notably, there were no cases of bile duct injury among the 50 patients, indicating a 100% success rate in avoiding this complication. Conclusion: We concluded that the achieving the Critical View of Safety during laparoscopic cholecystectomy is highly effective in preventing bile duct injuries. The postoperative outcomes highlight the procedure's safety and efficacy, reinforcing the importance of CVS in minimizing surgical complications.