This cross-sectional study investigated the association between serum electrolytes and blood glucose levels in 233 patients with Type 2 Diabetes Mellitus at Mahatma Gandhi Memorial Medical College and Hospital Jamshedpur Jharkhand. The findings revealed a significant negative correlation between sodium levels and fasting glucose. No significant correlations were found between potassium and chloride with glucose levels. Multiple regression analysis confirmed sodium as an independent predictor of fasting and postprandial glucose levels respectively. These results suggest that monitoring and managing electrolyte levels could play a crucial role in the metabolic control of diabetes patients.