Background: Cytological examination of body fluids is one of the commonly performed investigations.[1]. It helps to diagnose benign and malignant lesions of effusion.[2] The cell block particularly helps when cytological abnormalities are misleading in reactive mesothelial cells or adenocarcinoma.[3] In this study, we will be assessing and comparing the utility of cell block and conventional smear in fluid cytology. Methods: The present study was conducted in 55 samples of all body fluids (pleural, ascitic, synovial) obtained from patients, sent to the Cytopathology Section of the Department of Pathology, People’s college of medical science & Research Centre, Bhopal.All body fluid were analysed by both conventional smear and cell block methods. Result: Amongs 55 fluids, 37 cases of pleural fluid (67.3%), Ascitic fluid 15 cases (27.3%) and synovial fluid was noted in 3 cases (5.5%). Most common complains of pleural effusion (21.8%), followed by Tuberculosis with pleural effusion (14.5), Tuberculosis (9.1%), Pneumonia (9.1%) and Chronic liver disease (5.5%). Other causes were ascites with chronic liver disease (5.5%), synovitis were 3.6% and carcinoma of lung, colorectal carcinoma were (1.8%). The maximum number of samples were in the age group of more than 60 years (25.5%), Only 14.5% of patients were in the age group of 41-50 years. Male predominance 61% and 38.2% females in case of body fluids. Conclusion: Cell block technique helps to better appreciated on cellular morphology, Nuclear and cytoplasmic details. Sensitivity of cell block in malignant.