Background: Retinopathy of prematurity (ROP) is a neovascular vitreoretinal disorder occurring in premature infants. The present study assessed outcome of vitreoretinal surgery. Materials & Methods: 50 patients selected for vitreoretinal surgery of both genders were selected. Parameters such as duration of surgery time (min), the degree of pain (by using a 5-points verbal rating score: 0- no pain, 1-mild pain, 2-moderate pain, 3-severe pain, 4-unbearable pain) was recorded at 1 hour, 6 hours and 24 hours was recorded. Results: Out of 50 patients, males were 32 and females were 18.ASA physical status (I/II) was 27:23 patients. The mean weight was 62.4 kgs. The mean duration of surgery time (min) was 79.1, the onset time of sensory blocks (min) was 5.2 and the onset time of motor blocks (min) was 9.5. At 1 hour no pain was seen in 15, mild pain in11, moderate pain in 18 and severe pain in 6 patients. At 6 hours, no pain in 25, mild in 10, moderate in 12 and severe in 3 patients. At 24 hours, no pain was seen in 38, mild pain in 10, moderate pain in 2 patients. The difference was significant (P< 0.05). Conclusion: The most of the patients had no pain following vitreoretinal surgery after 24 hours.