Background: The prevalence of Skin disorders is towards the higher trend in developing countries, this makes them to be one of the most common health problems of India. There has been a high variability in histological spectrum observed. The histological diagnosis plays an important part in the treatment of the disease by the clinicians.Aim & Objectives: The study is aimed to study the spectrum of histopathological changes in skin biopsies. The objective of this study is to describe the morphological features in various skin diseases and to classify the skin lesions according to benign and malignant pathology.Methodology: A descriptive study done among patients with skin lesions from January 2022 to January 2023. The relevant clinical details were collected and analyzed for 216 patients. The different morphological patterns of the skin biopsies were described and categorised.Results: There was a slight preponderance in the occurrence of skin disease in males (54.6%) compared to females (45.4%). The most common site of the skin lesion was found to be the limbs (63.9%), with 46.37% in upper extremities and 53.62 in lower extremities. The most commonly observed skin disease were Non-infectious erythematous papular and squamous diseases 82(38%) and Non-infectious vesiculobullous and vesiculopustular diseases 44(20.4%) this was followed by 20(9.3%) of Neoplastic disease of skin and 18(8.3%) Microbial disease of skin. Conclusion: Morphological variations needs to be ascertained to arrive at a good diagnosis for improving the quality of life of patients with skin ailments.