Aim:To study the use ultrasound guidance to administer platelet-rich plasma or corticosteroid for the treatment of supraspinatus tendinosis or partial rupture.Material and methods: Observational research was done at the orthopaedics department to assess clinical outcomes. Both treatment techniques, namely USG guided PRP and CS, were regularly used in this study, with a total of 120 patients evenly distributed between the PRP and CS groups (60 patients in each group). The research comprised patients of both genders, aged between 20 and 50 years, who had a positive clinical test for supraspinatus tendinopathy and an MRI that indicated supraspinatus tendinitis. After clinically and radiologically confirming the diagnosis, they provided the patients were given either CS or 2.5 ml of PRP with local anaesthetic (2.5 ml of 2% lidocaine) under USG supervision. The patients were monitored and evaluated at 6 weeks, 3 months, and 6 months using the Visual Analog Scale (VAS) to assess shoulder discomfort, activity level, and satisfaction. Results:At admission, the average haemoglobin level was 10.8 ± 1.7 g/dL in the PRP group and 11.0 ± 1.5 g/dL in the CS group, showing no significant difference (P = 0.54). Preoperative haemoglobin levels were also similar, with the PRP group at 11.5 ± 1.4 g/dL and the CS group at 11.3 ± 1.6 g/dL (P = 0.68). Before discharge, haemoglobin levels averaged 10.3 ± 1.2 g/dL in the PRP group and 10.5 ± 1.0 g/dL in the CS group (P = 0.45). Regarding transfusions, 5% of PRP patients and 3.3% of CS patients received pre-surgery transfusions (P = 0.65), 6.7% in both groups required intra-surgery transfusions, and 3.3% in the PRP group versus 6.7% in the CS group received post-surgery transfusions (P = 0.68). These results show no significant differences in haemoglobin levels or transfusion rates between the two groups, indicating comparable perioperative management.Functional outcomes and patient satisfaction was assessed by the Harris Hip Score and patient satisfaction ratings at various time points.The Score was 85 ± 10 in the PRP group and 84 ± 9 in the CS group (P = 0.72), indicating similar functional outcomes. Patient satisfaction at 30 days post-surgery was 7.8 ± 1.2 in the PRP group and 7.6 ± 1.4 in the CS group (P = 0.57). At 60 days, satisfaction scores were 7.9 ± 1.1 for PRP patients and 7.7 ± 1.3 for CS patients (P = 0.65). After 1 year, satisfaction was rated at 8.0 ± 1.0 in the PRP group and 7.8 ± 1.2 in the CS group (P = 0.62).Conclusion:The results of this study demonstrate that ultrasound-guided PRP and CS injections for supraspinatus tendinosis or partial tear provide comparable outcomes in terms of demographics, surgery-related parameters, hemoglobin levels, transfusion requirements, complications, mortality, functional outcomes, and patient satisfaction. These findings are consistent with those of other studies, reinforcing the reliability and validity of the results. Further research with larger sample sizes and longer follow-up periods is warranted to confirm these findings and to explore the potential long-term benefits of PRP and CS treatments.